I have played over 3,000 gigs and recorded hundreds of songs over the past 35 years. 100% of my live gigs, I played my 1979 Les Paul Custom. And 90% of my studio work, I have recorded with my Les Paul. And yes I've played Paul Reed Smiths, which are fantastic but to me lack personality. Les Paul Customs have tons of personality. Personality to me means when I fidget with my picking, I can get lots of variations of tone. With the PRS, the tone is definitely beautiful, but it's much more uniform. Relative to a 'Paul, a PRS is a tiny bit bland. I say a tiny bit because I acknowledge that a PRS is a rip-roaring guitar for blues, classic rock, Latin Rock (Santana), pop, and Country (as long as you're not trying for very twangy.)
I have tried over one hundred electric guitars and the two best guitars I have ever played are, number two, my 1980s G&L Skyhawk (which is a hand made Stratocaster, made by Leo Fender's company, and with pickups wound by Leo Fender himself) and number one, my 1979 Les Paul Custom. I play both guitars through a 1979 Mesa Boogie Mark IIA amp. The tone of both guitars is spectacular, especially with this amp. The Les Paul gets the edge over the G&L because, with the amp turned at 100% volume on gain and master, the Custom's sound is still perfectly CLEAN and MEAN. At those fantastic volumes and with all that overdrive, the Skyhawk is a little bit dirty and, although it has fantastic sustain and thickness, it is not as thick, clean and sustaining as the Les Paul.
If money is no object, and if you want a guitar so durable you will leave it to your children, you should definitely buy a Les Paul Custom. Also, if you want beautiful silky clean tone, or thick, semi-crunch bluesy, classic rock crunch, or classic Metal guitar tones, you MUST get some generation of a Mesa Boogie "Mark" amp. In fact, to me, you should not waste money on a Les Paul Custom unless you're going to play it through a Marshall, Boogie, Vox, or other top of the line tube amp.
If you want to hear how MONSTER the Les Paul can sound, check out my Black Magic Woman video or my "OA" (which is Hotel California) videos at: youtube.com/ajmora.
Rock on guitar players!